Dados do Trabalho

Título

PREVALENCE OF USE OF TERATOGENIC ANTIEPILEPTIC DRUGS IN FEMALE PATIENTS REFERRED TO THE TRANSITION AMBULATORY OF EPILEPSY

Introdução

Adolescents diagnosed with epilepsy are patients who need specific care, especially girls of childbearing age. Considering that two of the main antiepileptic medications can have teratogenic effects, it is extremely important that these patients receive adequate guidance in their process of maturation and introduction to adulthood, without prejudice to seizure control.

Objetivo

To analyze the prevalence of the use of sodium valproate and carbamazepine in female patients of childbearing age diagnosed with epilepsy.

Métodos

This work is a cross-sectional study in which a survey was carried out of the medical records of the Transition Ambulatory of Epilepsy, in the first half of 2022, of female patients with epilepsy referred from external and internal services.

Resultados

Were identified 16 medical records of female patients, between 12 and 18 years old, with epilepsy undergoing pharmacological treatment. After multivariate analysis, it was found that 50% of these patients were using teratogenic antiepileptic medication.

Conclusões

Adolescents with epilepsy constitute a distinct group with physical, psychological and social needs, significantly different from those of adolescents without comorbidities. As a result, they need special attention, mainly young people of childbearing age. Therefore, the Transition Ambulatory of Epilepsy is crucial for these patients throughout their maturation process, in favor of adopting the best therapy, according to their needs and reducing future risks.

Palavras chave

transition ambulatory of epilepsy; adolescent of childbearing age; teratogenic antiepileptic drugs; sodium valproate; carbamazepine.

Referências (se houver)

1. Tomson, Torbjörna; Battino, Dinab; Perucca, Emilioc. Teratogenicity of antiepileptic drugs. Current Opinion in Neurology: April 2019 - Volume 32.

2. Laue-Gizzi H. Discontinuation of antiepileptic drugs in adults with epilepsy. Aust Prescr. 2021 Apr;44(2):53-56.

3. L. Kirkpatrick, A. Collins, Y. Sogawa, M. Birru Talabi, E. Harrison, T.M. Kazmerski. Sexual and reproductive healthcare for adolescent and young adult women with epilepsy: a qualitative study of pediatric neurologists and epileptologists; Epilepsy Behav, 104 (2020), p. 106911.

Declaração de conflito de interesses de TODOS os autores

Declaramos não estarmos submetidos a qualquer tipo de conflito de interesse, direto ou indireto, para o desenvolvimento do projeto de pesquisa intitulado "PREVALENCE OF USE OF TERATOGENIC ANTIEPILEPTIC DRUGS IN FEMALE PATIENTS REFERRED TO THE TRANSITION AMBULATORY OF EPILEPSY", cujo os pesquisadores envolvidos são os autores previamente inscritos nesse trabalho.